Vitiligo Care Tips] Daily Products vs Occupational Exposure: Understanding Chemical Leukoderma

In addition to autoimmune vitiligo, another form of pigment loss known as Chemical Leukoderma can also occur due to exposure to specific chemical agents that damage melanocytes.

This condition may be triggered by phenolic compounds found in certain cosmetic, industrial, or occupational products. Individuals with a predisposition to vitiligo—such as those with a family history or autoimmune tendencies—are particularly susceptible.

🔍 High-risk sources can be categorized into two main groups:
📌 Everyday consumer products:

• Hair dyes (e.g., PPD - para-phenylenediamine)

• Whitening or specialized skincare products (especially those previously containing rhododendrol)

• Preservative-containing skincare or topical medications (e.g., phenol)

• Essential oils and natural fragrances containing eugenol or related phenolic components

📌 Occupational or industrial exposures:

• Rubber manufacturing (catechol, MBEH)

• Textile/leather dyeing, photographic chemicals

• Industrial cleaners, wood treatment agents, and metal processing fluids

🔬 Chemical Leukoderma vs Vitiligo—How to tell the difference?

• Chemical leukoderma typically appears at areas of known chemical contact

• Vitiligo is often symmetrical, and may be associated with systemic autoimmune conditions
  → Dermatological consultation with dermoscopy, history taking, and immunological workup is recommended.
  

👨‍⚕️ Dr. Chau Yee Ng recommends:

• Avoid prolonged exposure to high-risk chemicals, especially on sensitive areas like hands, hairline, wrists, and ears

• Read ingredient labels carefully and avoid unverified DIY treatments

• Seek medical advice early if new depigmented patches appear